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KMID : 0364020120450010030
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Korean Journal of Thoracic and Cardiovascular Surgery
2012 Volume.45 No. 1 p.30 ~ p.34
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Midterm Follow-up after Cryopreserved Homograft Replacement in the Aortic Position
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Park Samina
Hwang Ho-Young
Kim Kyung-Hwan
Kim Ki-Bong
Ahn Hyuk
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Abstract
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Background: The long-term results of homografts used in systemic circulation are controversial. We assessed the long-term results of using a cryopreserved homograft for an aortic root or aorta and its branch replacement.
Materials and Methods: From June 1995 to January 2010, 23 patients (male:female=15:8, 45.4±15.6 years) underwent a homograft replacement in the aortic position. The surgical techniques used were aortic root replacement in 15 patients and aortic graft interposition in 8 patients. Indications for the use of a homograft were systemic vasculitis (n=15) and complicated infection (n=8). The duration of clinical follow-up was 65±58 months.
Results: Early mortality occurred in 2 patients (8.7%). Perioperative complications included atrial arrhythmia (n=3), acute renal failure (n=3), and low cardiac output syndrome (n=2). Late mortality occurred in 6 patients (26.1%). The overall survival rates at 5 and 10 years were 66.3% and 59.6%, respectively. Six patients (28.6%) suffered from homograft-related complications.
Conclusion: Early results of homograft replacement in aortic position were favorable. However, close long-term follow-up is required due to the high rate of homograft-related events.
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KEYWORD
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Homograft, Endocarditis, Aortic root, Aorta
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